SS-31 (Elamipretide) is a synthetic tetrapeptide studied in preclinical mitochondrial biology research for its role in cardiolipin binding and ATP synthesis pathway analysis.
SS-31, also known by the research name Elamipretide, is a synthetic cell-penetrating tetrapeptide. CAS: 736992-21-5. Unlike many research peptides that act at cell-surface receptors, SS-31 is designed to cross cellular and mitochondrial membranes directly, concentrating at the inner mitochondrial membrane. This localization is the basis for its use as a tool compound in preclinical mitochondrial bioenergetics and cellular aging research.
SS-31's proposed mechanism centers on selective binding to cardiolipin, a phospholipid concentrated in the inner mitochondrial membrane and essential to cristae architecture. By stabilizing cardiolipin, SS-31 has been studied for its ability to preserve the structural folding of the inner membrane, support efficient electron transport chain complex assembly, and reduce electron leakage that contributes to reactive oxygen species (ROS) formation. This mechanism distinguishes SS-31 from antioxidants that act only after ROS are produced, since it is studied as acting upstream, at the source of mitochondrial electron transport.
NuvoTide's SS-31 is supplied as a lyophilized powder, HPLC verified to ≥99% purity, and should be stored at -20°C prior to reconstitution. All NuvoTide Research products, including SS-31, are supplied strictly for in-vitro laboratory research purposes and are not intended for human or veterinary use, and are not FDA-approved.
For in-vitro research use only. Not for human or veterinary use.