Epithalon is a synthetic tetrapeptide studied in preclinical aging research for its role in telomerase activation and epigenetic regulation in controlled laboratory settings.
Epithalon (also referenced as Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG). CAS: 307297-39-8. It is a synthetic analogue of epithalamin, a peptide preparation originally isolated from the pineal gland. Research interest in Epithalon centers on its proposed effects on telomerase activity, circadian regulation, and gene expression in aging cell models, making it a frequently referenced compound in preclinical longevity biology research.
Epithalon's primary research interest lies in its proposed interaction with the promoter region of the human telomerase reverse transcriptase (hTERT) gene. In cultured human somatic cells, exposure to the AEDG sequence has been associated with increased telomerase activity, a key factor in cellular replicative capacity. Separately, as a member of the pineal peptide family, Epithalon has been studied for its influence on circadian pacemaker function, particularly the regulation of melatonin secretion patterns in animal models.
NuvoTide's Epithalon is supplied as a lyophilized powder, HPLC verified to ≥99% purity, and should be stored at -20°C prior to reconstitution. All NuvoTide Research products, including Epithalon, are supplied strictly for in-vitro laboratory research purposes and are not intended for human or veterinary use, and are not FDA-approved.
For in-vitro research use only. Not for human or veterinary use.